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| 3: Folia Microbiol (Praha) 1992;37(1):3-11 |
Betina V.
Department of Microbiology, Biochemistry and Biology, Faculty of Chemical
Technology, Slovak Technical University, Bratislava.
Brefeldin A has been recently characterized to act as an inhibitor of
intracellular protein export with profound effects on the structure and function
of the Golgi apparatus in animal cells. Manifold activities of the antibiotic
(under different names) published in the 1960's and 1970's are reviewed: effects
on fungal growth and morphogenesis, inhibition of mitosis in plant cells,
cytotoxicity, cancerostatic, antiviral and antinematodal activity and peculiar
effects on DNA, RNA and protein synthesis in microbial and animal cells.
Publication Types:
PMID: 1505860
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